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GW1516: Pros and Cons

GW1516 – even the name is mysterious. And sure enough, if you consult online discussion boards, you will notice an element of mystery surrounding the drug. No one seems to be certain as to just how much the average dosage should be; there is still debate even over the merits of the drug. There are those praising the benefits of the drug; on the other hand, there are those who either claim it makes no difference at all or it actually is more damaging than it is helpful. It seems to be a particularly popular subject among athletes and bodybuilders, alongside those scientists trying to modify the compound. To help shed some light on the matter, here is a brief pros-and-cons list regarding the GW1516:


As for the pros, it has been shown that the protein the drug affects is the peroxisome proliferator-activated receptor delta (or the PPAR delta).


This protein is involved in many biological processes, and seems to have a hand in the development of diseases like cancer, diabetes, obesity, and atherosclerosis, among others. The use of the drug, as originally intended, would be to serve as treatment for these diseases.



In animal testing, it has also been shown to increase endurance in mice. In rats, the upregulation of the expression of proteins—this is directly involved in energy use—was noted. Increased metabolism of fatty acid in skeletal muscle was likewise observed. In obese rhesus monkeys, increased levels of high-density lipoprotein with corresponding decreases in very low density lipoprotein were noted. The drug has also been shown to protect against diet-induced obesity and Type II diabetes. Furthermore, it was observed that GW1516 allows the metabolism to burn fat for energy instead of using carbohydrates and muscle protein. Aside from this, it was shown that the drug is responsible for increasing muscle mass while at the same time decreasing fat mass. Because of these factors, the compound is highly popular with athletes and bodybuilders.


As for the cons, note that the World Anti-Doping Agency has classified the drug as a hormone and metabolic modulator, landing on its list of prohibited substances in 2009. A number of professional athletes have already been sacked because of the illegal use of the drug. It is not only the World Anti-Doping Agency that is against the use of the drug; even governments have joined in the fray, prohibiting it in athletic events. The World Anti-Doping Agency said in a statement in 2013 that potential users should steer clear of the drug, especially as it was never approved—and never will, as the Agency claimed.


Furthermore, note that the original developer, GSK, was the one who shelved its own GW1516 project. By the end of almost two decades of research and testing, it was apparent that the compound caused cancers in rats—in the brain, liver, intestines, tongue, skin, testes, ovaries, and even in the womb. Earlier studies at around 2003 also pointed to increased polyps in genetically-engineered mice used as test subjects, but these claims were rebuffed by GSK, asserting that no adverse effects have been noted by then. By 2013, however, the cancer-causing properties of the compound were already well publicized.


These are just some of the pros and cons of using the GW1516. Since GSK shelved its own project—perhaps a sign of frustration or recognition of futility—many believe that the compound can still be modified and perhaps perfected, and this attracts scientists. The near-obscurity of this drug also contributes to the fascination many still seem to have—many buy the drug, preferring to see by themselves the benefits that it brings.

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Author | Kyle Baron Comments | 0 Date | April 11, 2016